Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

Transgenic mice expressing exon 1 of the human Huntington’s disease (HD) gene carrying a 141–157 CAG repeat (line R6/2) develop a progressive neurological phenotype with motor symptoms resembling those seen in HD. We have characterized the motor deficits in R6/2 mice using a battery of behavioral te...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Carter, Rebecca J., Lione, Lisa A., Humby, Trevor, Mangiarini, Laura, Mahal, Amarbirpal, Bates, Gillian P., Dunnett, Stephen B., Morton, A. Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782264/
https://ncbi.nlm.nih.gov/pubmed/10191337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-08-03248.1999
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