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A “Link-Psi” strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable
Using a combined crosslinking-ψ analysis strategy, we examine whether the structural content of the transition state of ubiquitin can be altered. A synthetic dichloroacetone crosslink is first introduced across two β strands. Whether the structural content in the transition state ensemble has shifte...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403417/ https://ncbi.nlm.nih.gov/pubmed/22528473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2065 |
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