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Intra-molecular cross-linking evaluated as a structural probe of the protein folding transition state
We examine the utility of intra-molecular covalent cross-linking to identify the structure present in the folding transition state. In mammalian ubiquitin, cysteine residues located across two β-strands are cross-linked with dichloroacetone. The kinetic effects of these covalent cross-links in ubiqu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307222/ https://ncbi.nlm.nih.gov/pubmed/17985931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701042e |
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