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Intra-molecular cross-linking evaluated as a structural probe of the protein folding transition state

We examine the utility of intra-molecular covalent cross-linking to identify the structure present in the folding transition state. In mammalian ubiquitin, cysteine residues located across two β-strands are cross-linked with dichloroacetone. The kinetic effects of these covalent cross-links in ubiqu...

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Bibliographic Details
Main Authors: Shandiz, Ali T., Capraro, Benjamin R., Sosnick, Tobin R.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307222/
https://ncbi.nlm.nih.gov/pubmed/17985931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701042e
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