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Probing the folding transition state of ubiquitin mutants by temperature-jump induced downhill unfolding

Crucial to revealing mechanistic details of protein folding is a characterization of the transition state ensemble and its structural dynamics. To probe the transition state of ubiquitin thermal unfolding, we examine unfolding dynamics and kinetics of wildtype and mutant ubiquitin using time-resolve...

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Detalhes bibliográficos
Main Authors: Chung, Hoi Sung, Shandiz, Ali, Sosnick, Tobin R., Tokmakoff, Andrei
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319365/
https://ncbi.nlm.nih.gov/pubmed/19053229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801603e
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