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A “Link-Psi” strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable

Using a combined crosslinking-ψ analysis strategy, we examine whether the structural content of the transition state of ubiquitin can be altered. A synthetic dichloroacetone crosslink is first introduced across two β strands. Whether the structural content in the transition state ensemble has shifte...

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Autori principali: Shandiz, Ali T, Baxa, Michael C, Sosnick, Tobin R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley Subscription Services, Inc., A Wiley Company 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403417/
https://ncbi.nlm.nih.gov/pubmed/22528473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2065
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