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A RUNX2–HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation
The osteogenic and oncogenic transcription factor RUNX2 downregulates the RNA polymerase I (RNA Pol I)-mediated transcription of rRNAs and changes histone modifications associated with the rDNA repeat. However, the mechanisms by which RUNX2 suppresses rRNA transcription are not well understood. RUNX...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Company of Biologists
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3403236/ https://ncbi.nlm.nih.gov/pubmed/22393235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.100909 |
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