A RUNX2–HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation

The osteogenic and oncogenic transcription factor RUNX2 downregulates the RNA polymerase I (RNA Pol I)-mediated transcription of rRNAs and changes histone modifications associated with the rDNA repeat. However, the mechanisms by which RUNX2 suppresses rRNA transcription are not well understood. RUNX...

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Detaylı Bibliyografya
Asıl Yazarlar: Ali, Syed A., Dobson, Jason R., Lian, Jane B., Stein, Janet L., van Wijnen, Andre J., Zaidi, Sayyed K., Stein, Gary S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Company of Biologists 2012
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403236/
https://ncbi.nlm.nih.gov/pubmed/22393235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.100909
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