Heparan Sulfate Enhances the Self-Renewal and Therapeutic Potential of Mesenchymal Stem Cells from Human Adult Bone Marrow

Insufficient cell number hampers therapies utilizing adult human mesenchymal stem cells (hMSCs) and current ex vivo expansion strategies lead to a loss of multipotentiality. Here we show that supplementation with an embryonic form of heparan sulfate (HS-2) can both increase the initial recovery of h...

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Autors principals: Helledie, Torben, Dombrowski, Christian, Rai, Bina, Lim, Zophia X.H., Hin, Ian Lee Hock, Rider, David A., Stein, Gary S., Hong, Wanjin, van Wijnen, Andre J., Hui, James H., Nurcombe, Victor, Cool, Simon M.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Original Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402859/
https://ncbi.nlm.nih.gov/pubmed/22066689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2011.0367
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