Massively parallel functional dissection of mammalian enhancers in vivo

The functional consequences of genetic variation in mammalian regulatory elements are poorly understood. We report the in vivo dissection of three mammalian liver enhancers at single nucleotide resolution via a massively parallelized reporter assay. For each enhancer, we synthesized a library of >...

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Hauptverfasser: Patwardhan, Rupali P, Hiatt, Joseph B, Witten, Daniela M, Kim, Mee J, Smith, Robin P, May, Dalit, Lee, Choli, Andrie, Jennifer M, Lee, Su-In, Cooper, Gregory M, Ahituv, Nadav, Pennacchio, Len A, Shendure, Jay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402344/
https://ncbi.nlm.nih.gov/pubmed/22371081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2136
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