Massively parallel functional dissection of mammalian enhancers in vivo

The functional consequences of genetic variation in mammalian regulatory elements are poorly understood. We report the in vivo dissection of three mammalian liver enhancers at single nucleotide resolution via a massively parallelized reporter assay. For each enhancer, we synthesized a library of >...

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Detalhes bibliográficos
Main Authors: Patwardhan, Rupali P, Hiatt, Joseph B, Witten, Daniela M, Kim, Mee J, Smith, Robin P, May, Dalit, Lee, Choli, Andrie, Jennifer M, Lee, Su-In, Cooper, Gregory M, Ahituv, Nadav, Pennacchio, Len A, Shendure, Jay
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402344/
https://ncbi.nlm.nih.gov/pubmed/22371081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2136
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