Autoantigen-Specific B-Cell Depletion Overcomes Failed Immune Tolerance in Type 1 Diabetes

Eliminating autoantigen-specific B cells is an attractive alternative to global B-cell depletion for autoimmune disease treatment. To identify the potential for targeting a key autoimmune B-cell specificity in type 1 diabetes, insulin-binding B cells were tracked within a polyclonal repertoire using...

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Bibliographic Details
Main Authors: Henry, Rachel A., Kendall, Peggy L., Thomas, James W.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2012
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402296/
https://ncbi.nlm.nih.gov/pubmed/22698916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1746
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