Cellular Uptakes, Biostabilities and Anti-miR-210 Activities of Chiral Arginine-PNAs in Leukaemic K562 Cells

A series of 18-mer peptide nucleic acids (PNAs) targeted against micro-RNA miR-210 was synthesised and tested in a cellular system. Unmodified PNAs, R(8)-conjugated PNAs and modified PNAs containing eight arginine residues on the backbone, either as C2-modified (R) or C5-modified (S) monomers, all w...

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Detalhes bibliográficos
Main Authors: Manicardi, Alex, Fabbri, Enrica, Tedeschi, Tullia, Sforza, Stefano, Bianchi, Nicoletta, Brognara, Eleonora, Gambari, Roberto, Marchelli, Rosangela, Corradini, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401907/
https://ncbi.nlm.nih.gov/pubmed/22639449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100745
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