C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells

The K562 cell line has been proposed as a useful experimental system to identify anti-tumor compounds acting by inducing terminal erythroid differentiation. K562 cells exhibit a low proportion of hemoglobin-synthesizing cells under standard cell growth conditions, but are able to undergo terminal er...

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Hlavní autoři: Brognara, Eleonora, Lampronti, Ilaria, Breveglieri, Giulia, Accetta, Alessandro, Corradini, Roberto, Manicardi, Alex, Borgatti, Monica, Canella, Alessandro, Multineddu, Chiara, Marchelli, Rosangela, Gambari, Roberto
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2011
Témata:
Molecular and Cellular Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271358/
https://ncbi.nlm.nih.gov/pubmed/21958870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2011.09.024
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