THE ISOPRENOID SUBSTRATE SPECIFICITY OF ISOPRENYLCYSTEINE CARBOXYLMETHYLTRANSFERASE: DEVELOPMENT OF NOVEL INHIBITORS()

Isoprenylcysteine carboxylmethyltransferase (Icmt) is an integral membrane protein localized to the endoplasmic reticulum of eukaryotic cells that catalyzes the post-translational α-carboxylmethylesterification of CaaX motif proteins, including the oncoprotein Ras. Prior to methylation, these protei...

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Bibliographische Detailangaben
Hauptverfasser: Anderson, Jessica L., Henriksen, Brian S., Gibbs, Richard A., Hrycyna, Christine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401627/
https://ncbi.nlm.nih.gov/pubmed/15946942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504982200
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