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Oxycodone Induces Overexpression of P-Glycoprotein (ABCB1) and Affects Paclitaxel’s Tissue Distribution in Sprague Dawley Rats

Previous studies suggest that P-glycoprotein (P-gp) modulates the PK/PD of many compounds including opioid agonists and chemotherapeutic agents. The objective of this study was to assess the P-gp affinity status of oxycodone, the P-gp expression, and the paclitaxel’s tissue distribution in oxycodone...

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Detalhes bibliográficos
Main Authors: HASSAN, HAZEM E., MYERS, ALAN L., LEE, INSONG J., COOP, ANDREW, EDDINGTON, NATALIE D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401599/
https://ncbi.nlm.nih.gov/pubmed/17593551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20893
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