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Oxycodone Induces Overexpression of P-Glycoprotein (ABCB1) and Affects Paclitaxel’s Tissue Distribution in Sprague Dawley Rats
Previous studies suggest that P-glycoprotein (P-gp) modulates the PK/PD of many compounds including opioid agonists and chemotherapeutic agents. The objective of this study was to assess the P-gp affinity status of oxycodone, the P-gp expression, and the paclitaxel’s tissue distribution in oxycodone...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401599/ https://ncbi.nlm.nih.gov/pubmed/17593551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20893 |
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