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Oxycodone Induces Overexpression of P-Glycoprotein (ABCB1) and Affects Paclitaxel’s Tissue Distribution in Sprague Dawley Rats
Previous studies suggest that P-glycoprotein (P-gp) modulates the PK/PD of many compounds including opioid agonists and chemotherapeutic agents. The objective of this study was to assess the P-gp affinity status of oxycodone, the P-gp expression, and the paclitaxel’s tissue distribution in oxycodone...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2007
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401599/ https://ncbi.nlm.nih.gov/pubmed/17593551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.20893 |
| Etiketak: |
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