The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase

Eukaryotic translation initiation is a highly regulated process in protein synthesis. The principal translation initiation factor eIF4AI displays helicase activity, unwinding secondary structures in the mRNAs 5′-UTR. Single molecule fluorescence resonance energy transfer (sm-FRET) is applied here to...

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Bibliographic Details
Main Authors: Sun, Yingjie, Atas, Evrim, Lindqvist, Lisa, Sonenberg, Nahum, Pelletier, Jerry, Meller, Amit
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401463/
https://ncbi.nlm.nih.gov/pubmed/22457067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks278
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