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Targeted Catalytic Inactivation of Angiotensin Converting Enzyme by Lisinopril-Coupled Transition Metal Chelates
A series of compounds that target reactive transition metal chelates to somatic Angiotensin Converting Enzyme (sACE-1) have been synthesized. Half maximal inhibitory concentrations (IC(50)) and rate constants for both inactivation and cleavage of full length sACE-1 have been determined and evaluated...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401419/ https://ncbi.nlm.nih.gov/pubmed/22200082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208791f |
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