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N- vs. C-Domain Selectivity of Catalytic Inactivation of Human Angiotensin Converting Enzyme by Lisinopril-Coupled Transition Metal Chelates

The N- and C-terminal domains of human somatic Angiotensin I Converting Enzyme (sACE-1) demonstrate distinct physiological functions, with resulting interest in the development of domain-selective inhibitors for specific therapeutic applications. Herein, the activity of lisinopril-coupled transition...

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Detalhes bibliográficos
Main Authors: Hocharoen, Lalintip, Joyner, Jeff C., Cowan, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052451/
https://ncbi.nlm.nih.gov/pubmed/24228790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4009345
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