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Activity-Dependent Alternative Splicing Increases Persistent Sodium Current and Promotes Seizure

Activity of voltage-gated Na channels (Na(v)) is modified by alternative splicing. However, whether altered splicing of human Na(v)s contributes to epilepsy remains to be conclusively shown. We show here that altered splicing of the Drosophila Na(v) (paralytic, DmNa(v)) contributes to seizure-like b...

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Autori principali: Lin, Wei-Hsiang, Günay, Cengiz, Marley, Richard, Prinz, Astrid A., Baines, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400946/
https://ncbi.nlm.nih.gov/pubmed/22623672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6042-11.2012
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