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Activity-Dependent Alternative Splicing Increases Persistent Sodium Current and Promotes Seizure
Activity of voltage-gated Na channels (Na(v)) is modified by alternative splicing. However, whether altered splicing of human Na(v)s contributes to epilepsy remains to be conclusively shown. We show here that altered splicing of the Drosophila Na(v) (paralytic, DmNa(v)) contributes to seizure-like b...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Society for Neuroscience
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3400946/ https://ncbi.nlm.nih.gov/pubmed/22623672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6042-11.2012 |
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