Mechanism for Calcium Ion Sensing by the C2A Domain of Synaptotagmin I

The C2A domain is one of two calcium ion (Ca(2+))- and membrane-binding domains within synaptotagmin I (Syt I), the identified Ca(2+) sensor for regulated exocytosis of neurotransmitter. We propose that the mechanistic basis for C2A's response to Ca(2+) and cellular function stems from marginal...

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Detalhes bibliográficos
Main Authors: Gauer, Jacob W., Sisk, Ryan, Murphy, Jesse R., Jacobson, Heathere, Sutton, R. Bryan, Gillispie, Gregory D., Hinderliter, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Membrane
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400769/
https://ncbi.nlm.nih.gov/pubmed/22853901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.05.051
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