Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

Cardiovascular death commonly occurs in patients with chronic kidney disease. Indoxyl sulfate (IS), a uremic toxin, has been demonstrated in vitro as a contributory factor in cardiac fibrosis, a typical pathological finding in uremic cardiomyopathy. This study aimed to determine if cardiac fibrosis...

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Autores principales: Lekawanvijit, Suree, Kompa, Andrew R., Manabe, Minako, Wang, Bing H., Langham, Robyn G., Nishijima, Fuyuhiko, Kelly, Darren J., Krum, Henry
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400638/
https://ncbi.nlm.nih.gov/pubmed/22829936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041281
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