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Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
BACKGROUND: Indoxyl sulfate, a uremic toxin, is accumulated in the serum of chronic kidney disease (CKD) patients, accelerating the progression of CKD. In CKD rat kidney, the expressions of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and its related genes are downregulated. AST-120, an oral s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3599003/ https://ncbi.nlm.nih.gov/pubmed/23496811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2369-14-56 |
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