Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells

Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). (Pro)renin receptor (PRR) is activated in the kidney of CKD. The present study aimed to determine the role of indoxyl sulfate (IS), a uremic toxin, in PRR activation in rat aorta and human aortic smoot...

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Detalhes bibliográficos
Main Authors: Yisireyili, Maimaiti, Saito, Shinichi, Abudureyimu, Shaniya, Adelibieke, Yelixiati, Ng, Hwee-Yeong, Nishijima, Fuyuhiko, Takeshita, Kyosuke, Murohara, Toyoaki, Niwa, Toshimitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208748/
https://ncbi.nlm.nih.gov/pubmed/25343458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109268
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