Cytosolic Entry of Shiga-Like Toxin A Chain from the Yeast Endoplasmic Reticulum Requires Catalytically Active Hrd1p

BACKGROUND: Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes. Currently, no molecular details of the dislocation process are available. To i...

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Bibliographic Details
Main Authors: Li, Shuyu, Spooner, Robert A., Hampton, Randolph Y., Lord, J. Michael, Roberts, Lynne M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400632/
https://ncbi.nlm.nih.gov/pubmed/22829918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041119
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