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The Association of Shiga-like Toxin with Detergent-resistant Membranes Is Modulated by Glucosylceramide and Is an Essential Requirement in the Endoplasmic Reticulum for a Cytotoxic Effect

Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx). Recently, it has been proposed that the obser...

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Main Authors: Smith, Daniel C., Sillence, Daniel J., Falguières, Thomas, Jarvis, Rosemary M., Johannes, Ludger, Lord, J. Michael, Platt, Frances M., Roberts, Lynne M.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382325/
https://ncbi.nlm.nih.gov/pubmed/16381816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-11-1035
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