Evidence of Inbreeding Depression on Human Height

Stature is a classical and highly heritable complex trait, with 80%–90% of variation explained by genetic factors. In recent years, genome-wide association studies (GWAS) have successfully identified many common additive variants influencing human height; however, little attention has been given to...

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Autors principals: McQuillan, Ruth, Eklund, Niina, Pirastu, Nicola, Kuningas, Maris, McEvoy, Brian P., Esko, Tõnu, Corre, Tanguy, Davies, Gail, Kaakinen, Marika, Lyytikäinen, Leo-Pekka, Kristiansson, Kati, Havulinna, Aki S., Gögele, Martin, Vitart, Veronique, Tenesa, Albert, Aulchenko, Yurii, Hayward, Caroline, Johansson, Åsa, Boban, Mladen, Ulivi, Sheila, Robino, Antonietta, Boraska, Vesna, Igl, Wilmar, Wild, Sarah H., Zgaga, Lina, Amin, Najaf, Theodoratou, Evropi, Polašek, Ozren, Girotto, Giorgia, Lopez, Lorna M., Sala, Cinzia, Lahti, Jari, Laatikainen, Tiina, Prokopenko, Inga, Kals, Mart, Viikari, Jorma, Yang, Jian, Pouta, Anneli, Estrada, Karol, Hofman, Albert, Freimer, Nelson, Martin, Nicholas G., Kähönen, Mika, Milani, Lili, Heliövaara, Markku, Vartiainen, Erkki, Räikkönen, Katri, Masciullo, Corrado, Starr, John M., Hicks, Andrew A., Esposito, Laura, Kolčić, Ivana, Farrington, Susan M., Oostra, Ben, Zemunik, Tatijana, Campbell, Harry, Kirin, Mirna, Pehlic, Marina, Faletra, Flavio, Porteous, David, Pistis, Giorgio, Widén, Elisabeth, Salomaa, Veikko, Koskinen, Seppo, Fischer, Krista, Lehtimäki, Terho, Heath, Andrew, McCarthy, Mark I., Rivadeneira, Fernando, Montgomery, Grant W., Tiemeier, Henning, Hartikainen, Anna-Liisa, Madden, Pamela A. F., d'Adamo, Pio, Hastie, Nicholas D., Gyllensten, Ulf, Wright, Alan F., van Duijn, Cornelia M., Dunlop, Malcolm, Rudan, Igor, Gasparini, Paolo, Pramstaller, Peter P., Deary, Ian J., Toniolo, Daniela, Eriksson, Johan G., Jula, Antti, Raitakari, Olli T., Metspalu, Andres, Perola, Markus, Järvelin, Marjo-Riitta, Uitterlinden, André, Visscher, Peter M., Wilson, James F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400549/
https://ncbi.nlm.nih.gov/pubmed/22829771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002655
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