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6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site
Histone acetyltransferases are important enzymes that regulate various cellular functions, such as epigenetic control of DNA transcription. Development of HAT inhibitors with high selectivity and potency will provide powerful mechanistic tools for the elucidation of the biological functions of HATs...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3399519/ https://ncbi.nlm.nih.gov/pubmed/22100137 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.11.001 |
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