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False Discovery Rates of Protein Identifications: A Strike against the Two-Peptide Rule

Most proteomics studies attempt to maximize the number of peptide identifications and subsequently infer proteins containing two or more peptides as reliable protein identifications. In this study, we evaluate the effect of this “two-peptide” rule on protein identifications, using multiple search to...

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Autors principals: Gupta, Nitin, Pevzner, Pavel A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398614/
https://ncbi.nlm.nih.gov/pubmed/19627159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr9004794
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