Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase.
At concentrations normally used to inhibit eukaryotic type II topoisomerase activity (100-1000 micrograms/ml) novobiocin binds core histones. Approximately 15 moles of novobiocin bind per mole of histone resulting in histone precipitation from solution in either 0.15 M or 2 M NaCl. The interaction b...
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| Vydáno v: | Nucleic Acids Res |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
1986
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| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339807/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3714493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.9.3671 |
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