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Novobiocin precipitates histones at concentrations normally used to inhibit eukaryotic type II topoisomerase.
At concentrations normally used to inhibit eukaryotic type II topoisomerase activity (100-1000 micrograms/ml) novobiocin binds core histones. Approximately 15 moles of novobiocin bind per mole of histone resulting in histone precipitation from solution in either 0.15 M or 2 M NaCl. The interaction b...
Shranjeno v:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
1986
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC339807/ https://ncbi.nlm.nih.gov/pubmed/3714493 |
| Oznake: |
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