Plasma Neurofilament Heavy Chain Levels Correlate to Markers of Late Stage Disease Progression and Treatment Response in SOD1(G93A) Mice that Model ALS

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterised by progressive degeneration of motor neurons leading to death, typically within 3–5 years of symptom onset. The diagnosis of ALS is largely reliant on clinical assessment and electrophysiological...

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Main Authors: Lu, Ching-Hua, Petzold, Axel, Kalmar, Bernadett, Dick, James, Malaspina, Andrea, Greensmith, Linda
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397981/
https://ncbi.nlm.nih.gov/pubmed/22815892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040998
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