Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS and lead to SOD1 protein misfolding and aggregati...

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Autors principals: Novoselov, Sergey S., Mustill, Wendy J., Gray, Anna L., Dick, James R., Kanuga, Naheed, Kalmar, Bernadett, Greensmith, Linda, Cheetham, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758296/
https://ncbi.nlm.nih.gov/pubmed/24023695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073944
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