Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons in the spinal cord, brain stem, and motor cortex. Mutations in superoxide dismutase (SOD1) are associated with familial ALS and lead to SOD1 protein misfolding and aggregati...

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Detalhes bibliográficos
Main Authors: Novoselov, Sergey S., Mustill, Wendy J., Gray, Anna L., Dick, James R., Kanuga, Naheed, Kalmar, Bernadett, Greensmith, Linda, Cheetham, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758296/
https://ncbi.nlm.nih.gov/pubmed/24023695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073944
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