G146V Mutation at the Hinge Region of Actin Reveals a Myosin Class-specific Requirement of Actin Conformations for Motility

The G146V mutation in actin is dominant lethal in yeast. G146V actin filaments bind cofilin only minimally, presumably because cofilin binding requires the large and small actin domains to twist with respect to one another around the hinge region containing Gly-146, and the mutation inhibits that tw...

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Autori principali: Noguchi, Taro Q. P., Komori, Tomotaka, Umeki, Nobuhisa, Demizu, Noriyuki, Ito, Kohji, Iwane, Atsuko Hikikoshi, Tokuraku, Kiyotaka, Yanagida, Toshio, Uyeda, Taro Q. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397860/
https://ncbi.nlm.nih.gov/pubmed/22637580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.321752
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