Rapid Nucleotide Exchange Renders Asp-11 Mutant Actins Resistant to Depolymerizing Activity of Cofilin, Leading to Dominant Toxicity in Vivo

Conserved Asp-11 of actin is a part of the nucleotide binding pocket, and its mutation to Gln is dominant lethal in yeast, whereas the mutation to Asn in human α-actin dominantly causes congenital myopathy. To elucidate the molecular mechanism of those dominant negative effects, we prepared Dictyost...

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Main Authors: Umeki, Nobuhisa, Nakajima, Jun, Noguchi, Taro Q. P., Tokuraku, Kiyotaka, Nagasaki, Akira, Ito, Kohji, Hirose, Keiko, Uyeda, Taro Q. P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548484/
https://ncbi.nlm.nih.gov/pubmed/23212920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.404657
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