Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments

Recent studies have demonstrated that IgG-Fc fragments (Fcabs) can be engineered to form antigen-binding sites with antibody properties. Thus they may serve as an attractive alternative to conventional antibodies in therapeutic applications. The critical influence of Fc glycosylation on effector fun...

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Bibliografiske detaljer
Main Authors: Jez, Jakub, Antes, Bernhard, Castilho, Alexandra, Kainer, Manuela, Wiederkum, Susanne, Grass, Josephine, Rüker, Florian, Woisetschläger, Max, Steinkellner, Herta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397857/
https://ncbi.nlm.nih.gov/pubmed/22589538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360701
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