In Planta Protein Sialylation through Overexpression of the Respective Mammalian Pathway

Many therapeutic proteins are glycosylated and require terminal sialylation to attain full biological activity. Current manufacturing methods based on mammalian cell culture allow only limited control of this important posttranslational modification, which may lead to the generation of products with...

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Detalhes bibliográficos
Main Authors: Castilho, Alexandra, Strasser, Richard, Stadlmann, Johannes, Grass, Josephine, Jez, Jakub, Gattinger, Pia, Kunert, Renate, Quendler, Heribert, Pabst, Martin, Leonard, Renaud, Altmann, Friedrich, Steinkellner, Herta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871460/
https://ncbi.nlm.nih.gov/pubmed/20305285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.088401
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