Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-Galactosylated N-Glycan Profile

It is well established that proper N-glycosylation significantly influences the efficacy of monoclonal antibodies (mAbs). However, the specific immunological relevance of individual mAb-associated N-glycan structures is currently largely unknown, because of the heterogeneous N-glycan profiles of mAb...

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Autori principali: Strasser, Richard, Castilho, Alexandra, Stadlmann, Johannes, Kunert, Renate, Quendler, Heribert, Gattinger, Pia, Jez, Jakub, Rademacher, Thomas, Altmann, Friedrich, Mach, Lukas, Steinkellner, Herta
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Glycobiology and Extracellular Matrices
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742812/
https://ncbi.nlm.nih.gov/pubmed/19478090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014126
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