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Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments
Recent studies have demonstrated that IgG-Fc fragments (Fcabs) can be engineered to form antigen-binding sites with antibody properties. Thus they may serve as an attractive alternative to conventional antibodies in therapeutic applications. The critical influence of Fc glycosylation on effector fun...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3397857/ https://ncbi.nlm.nih.gov/pubmed/22589538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360701 |
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