Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments

Recent studies have demonstrated that IgG-Fc fragments (Fcabs) can be engineered to form antigen-binding sites with antibody properties. Thus they may serve as an attractive alternative to conventional antibodies in therapeutic applications. The critical influence of Fc glycosylation on effector fun...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Jez, Jakub, Antes, Bernhard, Castilho, Alexandra, Kainer, Manuela, Wiederkum, Susanne, Grass, Josephine, Rüker, Florian, Woisetschläger, Max, Steinkellner, Herta
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2012
الموضوعات:
Glycobiology and Extracellular Matrices
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397857/
https://ncbi.nlm.nih.gov/pubmed/22589538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360701
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة