Partial Enzymatic Deglycosylation Preserves the Structure of Cleaved Recombinant HIV-1 Envelope Glycoprotein Trimers

The trimeric envelope glycoprotein complex (Env) is the focus of vaccine development programs aimed at generating protective humoral responses to human immunodeficiency virus type 1 (HIV-1). N-Linked glycans, which constitute almost half of the molecular mass of the external Env domains, produce con...

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Detalhes bibliográficos
Main Authors: Depetris, Rafael S., Julien, Jean-Philippe, Khayat, Reza, Lee, Jeong Hyun, Pejchal, Robert, Katpally, Umesh, Cocco, Nicolette, Kachare, Milind, Massi, Evan, David, Kathryn B., Cupo, Albert, Marozsan, Andre J., Olson, William C., Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Moore, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397850/
https://ncbi.nlm.nih.gov/pubmed/22645128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371898
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