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The Melanosomal Protein PMEL17 as a Target for Antibody Drug Conjugate Therapy in Melanoma
Melanocytes uniquely express specialized genes required for pigment formation, some of which are maintained following their transformation to melanoma. Here we exploit this property to selectively target melanoma with an antibody drug conjugate (ADC) specific to PMEL17, the product of the SILV pigme...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3397835/ https://ncbi.nlm.nih.gov/pubmed/22613716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361485 |
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