Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia-Reperfusion Injury

BACKGROUND: In myocardial ischemia, induction of autophagy via the AMP-induced protein kinase (AMPK) pathway is protective, whereas reperfusion stimulates autophagy with BECLIN-1 upregulation, and is implicated in causing cell death. We examined flux through the macro-autophagy pathway as a determin...

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Autores principales: Ma, Xiucui, Liu, Haiyan, Foyil, Sarah R., Godar, Rebecca J., Weinheimer, Carla J., Hill, Joseph A., Diwan, Abhinav
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397471/
https://ncbi.nlm.nih.gov/pubmed/22592897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.041814
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