Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

To examine the temporal relationship of cortical autophagic flux with delayed neuronal cell death after hypoxia-ischemia (HI) in neonatal piglets. HI was produced with 45-min hypoxia and 7-min airway occlusion in 3–5-day-old piglets. Markers of autophagic, lysosomal and cell death signaling were stu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Cui, Derong, Sun, Dawei, Wang, Xintao, Yi, Liye, Kulikowicz, Ewa, Reyes, Michael, Zhu, Junchao, Yang, Zeng-Jin, Jiang, Wei, Koehler, Raymond C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550864/
https://ncbi.nlm.nih.gov/pubmed/28703794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.318
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