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Hypothermia and rewarming activate a macroglial unfolded protein response independent of hypoxic-ischemic brain injury in neonatal piglets

Therapeutic hypothermia provides incomplete neuroprotection after hypoxia-ischemia (HI)-induced brain injury in neonates. We previously showed that cortical neuron and white matter apoptosis are promoted by hypothermia and early rewarming in a piglet model of HI. The unfolded protein response (UPR)...

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Detalhes bibliográficos
Publicado no:Dev Neurosci
Main Authors: Lee, Jennifer K., Wang, Bing, Reyes, Michael, Armstrong, Jillian S., Kulikowicz, Ewa, Santos, Polan T., Lee, Jeong-Hoo, Koehler, Raymond C., Martin, Lee J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127731/
https://ncbi.nlm.nih.gov/pubmed/27622292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000448585
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