Regulation of the Transcription Factor EB-PGC1α Axis by Beclin-1 Controls Mitochondrial Quality and Cardiomyocyte Death under Stress

In cardiac ischemia-reperfusion injury, reactive oxygen species (ROS) generation and upregulation of the hypoxia-inducible protein BNIP3 result in mitochondrial permeabilization, but impairment in autophagic removal of damaged mitochondria provokes programmed cardiomyocyte death. BNIP3 expression an...

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Publicado no:Mol Cell Biol
Main Authors: Ma, Xiucui, Liu, Haiyan, Murphy, John T., Foyil, Sarah R., Godar, Rebecca J., Abuirqeba, Haedar, Weinheimer, Carla J., Barger, Philip M., Diwan, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333088/
https://ncbi.nlm.nih.gov/pubmed/25561470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01091-14
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