DOMINANT-NEGATIVE EFFECT OF TRUNCATED MANNOSE 6-PHOSPHATE/INSULIN-LIKE GROWTH FACTOR II RECEPTOR SPECIES IN CANCER*

Oligomerization of the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is important for optimal ligand binding and internalization. M6P/IGF2R is a tumor suppressor gene that exhibits loss of heterozygosity and is mutated in several cancers. We tested the potential dominant-neg...

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Hoofdauteurs: Kreiling, Jodi L., Montgomery, Michelle A., Wheeler, Joseph R., Kopanic, Jennifer L., Connelly, Christopher M., Zavorka, Megan E., Allison, Jenna L., MacDonald, Richard G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396780/
https://ncbi.nlm.nih.gov/pubmed/22681933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2012.08652.x
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