Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture

In this study, we have examined the properties of synaptic transmission between dorsal root ganglion (DRG) and dorsal horn (DH) neurons, placed in co-culture. We also examined the effect of the anti-hyperalgesic gabapentinoid drug pregabalin (PGB) at this pharmacologically relevant synapse. The main...

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Bibliographic Details
Main Authors: Hendrich, Janek, Bauer, Claudia S., Dolphin, Annette C.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396689/
https://ncbi.nlm.nih.gov/pubmed/22627148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/chan.19805
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