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Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling

SH2 domains are integral to many animal signaling pathways. By interacting with specific phosphotyrosine residues, they provide regulatable protein–protein interaction domains. Dictyostelium is the only nonmetazoan with functionally characterized SH2 domains, but the cognate tyrosine kinases are unk...

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Hlavní autoři: Araki, Tsuyoshi, Kawata, Takefumi, Williams, Jeffrey G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396520/
https://ncbi.nlm.nih.gov/pubmed/22699506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202715109
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